The Role of Chromosomal Aberration in Recurrent Pregnancy Loss (RPL)

By: Michelle Zhang, Walnut High School

Recurrent pregnancy loss (RPL) is a health condition that threatens the well-being of women. It is a condition where a woman experiences two or more consecutive pregnancy losses, often attributed to chromosomal aberrations. This study focused on assessing chromosomal abnormalities using a retrospective cohort approach. The sample size was 500 couples, consisting of 300 with a documented history of RPL and 200 with age-matched controls. Next-generation sequencing and karyotyping were used to assess the abnormalities in the collected blood and tissue samples. Basic descriptive analyses were performed to describe participants and their clinical profiles. The relationship between RPL risks and other specific chromosomal anomalies was conducted using chi-square tests and logistic regression. The findings indicated that 40% of cases in the test group had chromosomal abnormalities compared to 5% of the control group. Significant RPL risk was reported to be linked more with translocations and inversions.